This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
kortix marketplace install K-Dense-AI/scientific-agent-skills:aeonuv pip install "aeon==1.6.0"
uv pip install "aeon[all_extras]==1.6.0"
uv pip install "aeon[all_extras]==1.6.0".uv pip install "aeon==1.6.0" stumpy. Range precision/recall/F-score depend on prts, whose current NumPy<2 requirement conflicts with aeon 1.6; use the runnable AUC metrics or a separately validated environment. Deep learning estimators use TensorFlow. Inspect an estimator's python_dependencies tag before installing optional packages.references/classification.md for selected methods.from aeon.classification.convolution_based import RocketClassifier
from aeon.datasets import load_classification
# Load data
X_train, y_train = load_classification("GunPoint", split="train")
X_test, y_test = load_classification("GunPoint", split="test")
# Train classifier
clf = RocketClassifier(n_kernels=10000)
clf.fit(X_train, y_train)
accuracy = clf.score(X_test, y_test)
MiniRocketClassifier, ArsenalHIVECOTEV2, InceptionTimeClassifierShapeletTransformClassifier, Catch22ClassifierKNeighborsTimeSeriesClassifier with DTW distancereferences/regression.md for algorithms.from aeon.regression.convolution_based import RocketRegressor
from aeon.datasets import load_regression
X_train, y_train = load_regression("Covid3Month", split="train")
X_test, y_test = load_regression("Covid3Month", split="test")
reg = RocketRegressor()
reg.fit(X_train, y_train)
predictions = reg.predict(X_test)
references/clustering.md for methods.from aeon.clustering import TimeSeriesKMeans
clusterer = TimeSeriesKMeans(
n_clusters=3,
distance="dtw",
averaging_method="ba"
)
labels = clusterer.fit_predict(X_train)
centers = clusterer.cluster_centers_
references/forecasting.md for forecasters.import numpy as np
from aeon.forecasting import NaiveForecaster
from aeon.forecasting.stats import ARIMA
y_train = np.array([1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0, 10.0])
# predict returns one value at the configured horizon, not a 5-value vector
naive = NaiveForecaster(strategy="drift", horizon=5)
naive.fit(y_train)
y_at_5 = naive.predict(y_train) # 15.0
# ARIMA uses p/d/q (not order=); multi-step via iterative_forecast
arima = ARIMA(p=1, d=1, q=1)
y_pred = arima.iterative_forecast(y_train, prediction_horizon=5) # fits once
references/anomaly_detection.md for detectors.from aeon.anomaly_detection.series.distance_based import STOMP
detector = STOMP(window_size=50)
anomaly_scores = detector.fit_predict(y)
# Higher scores indicate anomalies
threshold = np.percentile(anomaly_scores, 95)
anomalies = anomaly_scores > threshold
references/segmentation.md.from aeon.segmentation import ClaSPSegmenter
segmenter = ClaSPSegmenter()
change_points = segmenter.fit_predict(y)
references/similarity_search.md.from aeon.similarity_search.subsequence import MASS
# X_train: (n_cases, n_channels, n_timepoints); query: (n_channels, 20)
searcher = MASS(length=20, normalize=True).fit(X_train)
query = X_train[0, :, :20]
indices, distances = searcher.predict(query, k=3, X_index=(0, 0))
# indices rows are (case_index, window_start); self-match is excluded
references/transformations.md.from aeon.transformations.collection.convolution_based import Rocket
rocket = Rocket()
X_features = rocket.fit_transform(X_train)
# Use features with any sklearn classifier
from sklearn.ensemble import RandomForestClassifier
clf = RandomForestClassifier()
clf.fit(X_features, y_train)
from aeon.transformations.collection.feature_based import Catch22
catch22 = Catch22()
X_features = catch22.fit_transform(X_train)
from aeon.transformations.collection import MinMaxScaler, Normalizer
scaler = Normalizer() # Z-normalization
X_normalized = scaler.fit_transform(X_train)
references/distances.md for selected distances.from aeon.distances import dtw_distance, dtw_pairwise_distance
# Single distance
distance = dtw_distance(x, y, window=0.1)
# Pairwise distances
distance_matrix = dtw_pairwise_distance(X_train)
# Use with classifiers
from aeon.classification.distance_based import KNeighborsTimeSeriesClassifier
clf = KNeighborsTimeSeriesClassifier(
n_neighbors=5,
distance="dtw",
distance_params={"window": 0.2}
)
references/networks.md.FCNClassifier, ResNetClassifier, InceptionTimeClassifierRecurrentNetwork; temporal convolution: TCNNetworkAEFCNClusterer, AEResNetClustererfrom aeon.classification.deep_learning import InceptionTimeClassifier
clf = InceptionTimeClassifier(n_epochs=100, batch_size=32)
clf.fit(X_train, y_train)
predictions = clf.predict(X_test)
references/datasets_benchmarking.md.from aeon.datasets import load_classification, load_gunpoint, load_regression
# Classification (generic loader or dataset-specific helper)
X_train, y_train = load_classification("GunPoint", split="train")
X_train, y_train = load_gunpoint(split="train") # same UCR dataset
# Regression
X_train, y_train = load_regression("Covid3Month", split="train")
from aeon.benchmarking.results_loaders import get_estimator_results
# Compare with published results
published = get_estimator_results("ROCKET", ["GunPoint"])
from aeon.transformations.collection import Normalizer
from aeon.classification.convolution_based import RocketClassifier
from sklearn.pipeline import Pipeline
pipeline = Pipeline([
('normalize', Normalizer()),
('classify', RocketClassifier())
])
pipeline.fit(X_train, y_train)
accuracy = pipeline.score(X_test, y_test)
from aeon.transformations.collection.convolution_based import Rocket
from sklearn.ensemble import GradientBoostingClassifier
# Extract features
rocket = Rocket()
X_train_features = rocket.fit_transform(X_train)
X_test_features = rocket.transform(X_test)
# Train traditional ML
clf = GradientBoostingClassifier()
clf.fit(X_train_features, y_train)
predictions = clf.predict(X_test_features)
from aeon.anomaly_detection.series.distance_based import STOMP
import matplotlib.pyplot as plt
detector = STOMP(window_size=50)
scores = detector.fit_predict(y)
plt.figure(figsize=(15, 5))
plt.subplot(2, 1, 1)
plt.plot(y, label='Time Series')
plt.subplot(2, 1, 2)
plt.plot(scores, label='Anomaly Scores', color='red')
plt.axhline(np.percentile(scores, 95), color='k', linestyle='--')
plt.show()
from aeon.transformations.collection import Normalizer
normalizer = Normalizer()
X_train = normalizer.fit_transform(X_train)
X_test = normalizer.transform(X_test)
from aeon.transformations.collection import SimpleImputer
imputer = SimpleImputer(strategy='mean')
X_train = imputer.fit_transform(X_train)
(n_cases, n_channels, n_timepoints); single series usually use (n_channels, n_timepoints) with axis=1. TimeEval loaders return timepoints by channels: use axis=0 where supported. Check capability tags for missing values, multivariate and unequal-length support (see data format)MiniRocketClassifierMiniRocketRegressorTimeSeriesKMeans with EuclideanHIVECOTEV2, InceptionTimeClassifierInceptionTimeRegressorAutoARIMA, AutoETS, TCNForecaster (TensorFlow dependency for deep learning)ShapeletTransformClassifier, Catch22ClassifierCatch22, TSFreshKNeighborsTimeSeriesClassifier with DTWreferences/:classification.md - Selected classification algorithmsregression.md - Regression methodsclustering.md - Clustering algorithmsforecasting.md - Forecasting approachesanomaly_detection.md - Anomaly detection methodssegmentation.md - Segmentation algorithmssimilarity_search.md - Pattern matching and motif discoverytransformations.md - Feature extraction and preprocessingdistances.md - Time series distance metricsnetworks.md - Deep learning architecturesdatasets_benchmarking.md - Data loading and evaluation toolsKassis, T., Agarwal, V., He, Y., Patel, D., & Brueckner, A. M. (2026). Scientific Agent Skills: A Library of Procedural Knowledge for Research Agents. arXiv:2609.00065. https://doi.org/10.48550/arXiv.2609.00065
v1. When network access is
available, fetch https://arxiv.org/abs/2609.00065 (or
http://export.arxiv.org/api/query?id_list=2609.00065)) before writing the reference and take
the author list, year, and version from that record. If the record lists a journal reference
or publisher DOI, cite the published version instead.Estimates intracellular metabolic fluxes from steady-state carbon-13 isotope-tracing measurements using validated atom maps, mfapy isotope simulation, constrained multistart fitting, and flux-profile diagnostics. Use for 13C-MFA, carbon tracing, mass isotopomer distributions (MDVs/MIDs), positional isotopomers, parallel tracer experiments, and determining whether labeling data constrain a pathway flux. Distinguishes measured-label inference from COBRA flux balance analysis and flags experiments requiring nonstationary MFA.
Uses the Adaptyv Bio Foundry API and Python SDK to design protein characterization experiments, estimate costs, submit sequences, monitor laboratory progress, and retrieve results. Applies to Adaptyv Foundry, its target catalog, binding screening and affinity assays, thermostability, expression, fluorescence, epitope binning, and enzyme activity workflows, including code using adaptyv or FoundryClient.
Looks up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18 SHAP feature attributions, plus raw and quantile scores for RNA-seq, DNase, ATAC, ChIP-TF, ChIP-histone, CAGE, PRO-cap, splicing, polyadenylation and contact-map tracks), scores variants or scans windows on demand with the AlphaGenome model for human and mouse (variant scoring, in silico mutagenesis, REF-versus-ALT track prediction), and builds Atlas website deep links. Use when the user mentions AlphaGenome, AlphaGenome Atlas, AVI or AlphaGenome Variant Impact, DeepMind variant effect prediction, or wants to prioritise or mechanistically interpret non-coding, regulatory, splicing, enhancer, promoter, or chromatin-accessibility effects of SNVs from a VCF, credible set, or region. Research use only; not a clinical tool.
Plans, executes, and documents validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.
Handles annotated matrices in single-cell analysis, .h5ad and Zarr files, and integration with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.
Applies Arbor Hypothesis Tree Refinement to research artifacts with repeatable evaluators, including model training, agent harnesses, data synthesis and benchmark optimization. Uses persistent hypotheses, isolated experiments, evidence propagation and held-out candidate comparison for multi-experiment research runs. Includes a standard-library state manager and guidance for the RUC-NLPIR Arbor CLI.